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You yell this at someone who’s so angry they look like they want to punch a wall and cry at the same time. It’s like telling them they’re a useless pile of garbage who can’t even handle a tiny problem.
I said 'mad as cheese' to my brother after he spilled his cereal and cried like a baby.
My mom yelled 'mad as cheese' at me when I told her I failed math again.
My friend screamed 'mad as cheese' at the guy who cut in front of him in line.